Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal

Background Bicuspid aortic valve (BAV) is a congenital cardiac deformity, increasing the risk of developing calcific aortic valve disease (CAVD).The disturbance of hemodynamics can induce valvular calcification, but the mechanism has not been fully identified.Methods We constructed a finite element model (FEM) of the aortic valve based on the compu

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Silver (I) N-Heterocyclic Carbenes Carbosilane Dendritic Systems and Their Imidazolium-Terminated Analogues as Antibacterial Agents: Study of Their Mode of Action

Spherical dendrimers and dendrons containing silver(I) N-heterocyclic carbenes (Ag(I)-NHC) and additionally bow-tie metal-free dendritic systems were synthesized in a simple and straightforward synthetic procedure royal nomadic 5413 rug and subsequently characterized.The antibacterial activity was evaluated, and in parallel, a comparative study wit

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